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This was long before Wegovy and Ozempic made GLP-1 a household term, making the marketing challenge particularly difficult

Cut way back on (or avoid) alcohol

Chronic stress increases appetite, promotes fat storage (particularly visceral fat), and disrupts insulin sensitivity

The indication is to effectively reduce glycosylated hemoglobin levels in patients with T2DM by reducing fasting and postprandial blood glucose levels (61, 62)

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Additionally, GLP-1 RAs exhibit neuroprotective and anti-inflammatory effects, increase Akt dephosphorylation, decrease proinflammatory factors such as TNF-, elevate neurotrophic factors like BDNF, reduce oxidative stress and microglial activation, and enhance gut-brain axis function and gut microbiota stability [176]