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Their analysis of 141 studies, published in the BMJ, indicates a 20-a-day habit would cause seven heart attacks or strokes in a group of 100 middle-aged people

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Here are the findings based on the subset of studies that adjusted for multiple confounders (e.g., cholesterol, blood pressure): Women who smoked 1 cigarette daily had a 119% increased risk for CHD and a 46% increased risk for stroke

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The BPRF is defined as either the 5th (if harmful) or 95th (if protective) quantile curve closest to the line of log(RR) of 0, which defines the null (Figs