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4.2 Females are relatively at higher risk of smoking-induced CVD Over the past 50 years, the risk of chronic diseases related to smoking in women has significantly increased, with CVD risks now comparable to those seen in men

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An often-cited lethal dose of nicotine is 30-60mg, but that estimate comes from a 1906 textbook on the subject and has become debatable under newer research

Last updated 19/12/2025

Using no tobacco products whatsoever is the best way to safeguard your health

Citing Doll and Hill, the journal declared that the most reasonable interpretation of this evidence is that the relationship is one of direct cause and effect. Ronald Fisher begged to differ