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All enrolled participants were weight stable, free from acute or chronic diseases, and did not eat a diet or take medications that might interfere with outcome markers including antioxidant supplements, high intake of dietary polyphenols including coffee, or anti-inflammatory medications

Identifying reliable biomarkers related to cysteine and homocysteine metabolism for diagnostic and prognostic purposes remains an ongoing challenge

Increased Cell Adhesion to Extracellular Matrix (ECM) Extracellular matrix is a non-cellular highly dynamic essential support structure within tissues (Ramteke et al., 2015)

Billing for injections is a common source of confusion and denial for healthcare professionals

The MVA pathway also plays a key role in GPX4 maturation, as isopentenyl pyrophosphate (IPP) contributes to the complicated insertion of selenocysteine into the catalytic center of GPX4, which is important for its antioxidant activity

Finally, considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, need further research studies