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Nicotine was also used as a treatment for intestinal parasites during the 19th century - an early edition of the United States Air Force Survival Handbook noted that, in extreme cases, eating a single cigarette can be used as a field remedy for intestinal parasites

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Moreover, the presence of ROS damages stem cells self-renewal activation and differentiation towards tissure-specific lineages like osteoblasts and osteocytes 53

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