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Weeks 9 through 12: 8mg once weekly

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1997 A model for p53-induced apoptosis Nature 389 : 300305 Kroemer G, Zamzami N, Susin SA

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In addition, cellular ROS accumulation inevitably causes intrinsic damage of both nuclear and mitochondrial DNA, resulting in the aberrant presence of cytosolic double-stranded DNA (dsDNA) fragments, which serve as strong agonist of cGAS-STING-dependent innate immune signaling pathway [36, 37]