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Generally, intramuscular or intradermal injection is used in animal models and human volunteers to elicit protection against infectious disease to maximize delivery to APCs, while intraperitoneal or intravenous injection has been used in selected animal models to induce systemic expression in therapeutic models, such as cancer vaccination (57)

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Second, a disturbing increase in later-onset, less frequent smoking by 18- to 25-year-olds could portend a growing cohort of new smokers who may be overlooked by traditional prevention programs for teens and by traditional cessation programs developed for older smokers