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In 2008, the World Health Organization predicted that within 2 years, cancer deaths could become the most common form of death in developing countries such as China and India, primarily due to the increased use of tobacco products in these countries

It highlights the importance of functional p53 in protecting skin cells from UVR damage, also suggesting that restoring wild-type p53 function could be a valuable strategy against skin cancer, especially non-melanoma skin cancers (NMSC)

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Once phosphorylated, c-Jun and c-Fos can dimerize to form the AP-1 transcription factor, which translocates to the nucleus, where it binds to specific DNA sequences known as AP-1 binding sites

To strengthen the repair and/or elimination of damaged molecules or the induction of cell death, the radiation-induced ROS, the oxidized products, and the DNA lesions activate different signaling pathways