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4, 87, 102, 119, and 206-210)

The plant genus Nicotiana has more than fifty species which are classified into four groups: Nicotiana tabacum, Nicotiana petunoides, Nicotiana rustica and Nicotiana polidiclia

These two features combined in order to drive high addiction rates among soldiers in World War I, to whom cigarettes were distributed without charge (Burns et al

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Pouches stored at room temperature for extended periods lose moisture, which slows and weakens nicotine release