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Starting in the 1970s, around the time of that legislation limiting advertising of tobacco products, people began to suddenly think about things like second-hand smoke and work environments

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Approximately 3.2 million deaths and 32.1 million DALYs (representing about 2.1% of global DALYs) each year are attributable to insufficient physical activity

This is consistent with the human study conducted by Carnevale et al., showing that the use of e-cigarettes increases oxidative stress/injury biomarkers, such as 8-isoprostanes in blood compared to non-smokers (Carnevale et al., 2016)