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Statistical differences were analyzed by unpaired Students t test, one-way ANOVA followed by Bonferroni posttest, or MannWhitney test

This allows timely adjustments and ensures safe, effective and data-driven fertility care

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Multiexonic polyA + eRNAs (meRNAs) are eRNAs produced by transcription initiation at enhancers in intragenic regions [42, 45]

Challenges and future directions Despite the importance of comprehending how epigenetic mechanisms operate in health and disease to develop novel therapeutic approaches in the treatment of human diseases, there are numerous difficulties associated with instigating targeted epigenetic modifications that aim to restore the epigenetic landscape to a normal physiological state from a diseased state