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Results Targeting of the common marmoset LRRK2 gene using CRISPR/Cas9 To evaluate whether it was feasible to introduce the PD LRRK2 G2019S mutation in the marmoset genome, we first compared marmoset and human LRRK2 protein sequences

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This study highlights the potential of AEP-mediated enzymatic cyclization as a powerful tool for generating structurally complex, cyclic peptide therapeuticsoffering a viable route to improving the pharmacological properties and therapeutic value of conotoxins beyond the reach of conventional chemical synthesis

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis

197 For therapeutic purposes, the specificity of the potent target sites would be the critical prerequisite for the development of new inhibitors of NLRP3 inflammasome

The Function of astragalus Polysaccharides in Hepatic Steatosis of Mice