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However, concerns remain about long-term risks, especially for youth

5 showed that ECVC resulted in more significant toxicity than ECL due to an increase in an AM inflammatory response resulting in increased apoptosis and necrosis from excessive production of reactive oxygen species (ROS) and inflammatory cytokines

Hydrogen cyanide is one of the tobaccos smoke poisonous substances which are formed from the combustion of the protein and nitrate compounds existed in tobacco at high temperatures in the oxygen deficient condition [5, 6] which its chronic and low exposure causes neurological, respiratory, cardiovascular and thyroid effect [79]

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