most tobacco producing country World production by 2024| Statista 3. Tobacco-producing countries, 2011 |

Deforestation: Tobacco farming is a major driver of deforestation, both for creating plantation space and for obtaining wood used in the energy-intensive curing process

Whilst I appreciate that CRUK have to be very considerate in terms of any position they take, and to be cautious with any statements to that effect, I do think it would to the Public Health community at large a world of good if they were to stop focusing entirely on statistical and chemical measurements, and actually *speak* to users of these devices and see the massive difference they make to their quality of life, and factor that into their studies and positions and without wishing to get to morbid, Im sure that quality of life is something CRUK would be familiar with for many of those it works with/for, and is not something that youd discount lightly

Manufacturing tobacco products

Controlled, low-dose nicotine, studied in patches, gum, or nasal sprays, is being investigated as an adjunct therapy for treatment-resistant depression and mood instability

Stress response pathways The expressions of various stress-related proteins, including heat-shock factor 1 (HSF1), heat-shock protein 90 (HSP90), heat-shock protein 27 (HSP27), and phosphorylated HSP27, and antioxidant enzymes, including superoxide dismutase 1 (SOD1), mitochondria SOD (SOD2), and phospholipid hydroperoxide glutathione peroxidase (GPx4), were measured among smokers and non-smokers

Tortoise pickguard with 5-ply binding has warped a bit, but no cracks