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The finishing component is, of course, genuine tobacco smoke

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Moreover, mecamylamine, but not dihydro--erythroidine (DHE) (antagonist with relative selectivity for 2* nAChRs, including 42* and 62*), increased the antidepressant-like effect of citalopram [67], suggesting that these nAChR subtypes are not involved in the antidepressant activity of SSRIs