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If they had been smokers, there wouldve been no way to isolate the causes and effects

The oxidative stress in smokers may well have contributed to their elevated AGE levels 6,61,62

Smoking, fat mass and activation of the tumor necrosis factor-alpha pathway

It's reasonable to assume that nonresponders are more likely continuing smokers, and in fact would be counted that way in many studies

This was previously set at the age of 16 before 2007
