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doi: 10.3109/01902149309064351 [DOI] [PubMed] [Google Scholar] 131

Agius et al.12 showed that cotinin, a toxic metabolite of nicotine is capable of significantly reducing the cilliary beat of epithelial cells in vitro

Tobacco smoke is made up of thousands of chemicals, including more than 70 that cause cancer

Cell 68 (2), 281292

Importantly, control cells, including BEAS-2B and human lung organoids, were passaged in parallel under the same culture conditions and duration as the WCSE-exposed cells, which allowed us to compare adaptive changes arising specifically from chronic smoke exposure rather than from prolonged culture alone

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