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1993;54(suppl):3541, discussion 5556

NAD-dependent reactions occur at a high rate during wakefulness, as evidenced by the accumulation of NADH in brain tissues during sleep deprivation [6]

10.1186/s12974-015-0350-4 105 Espinosa-DiezC.MiguelV.MennerichD.KietzmannT.Snchez-PrezP.CadenasS.et al

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(80.3) There is a report that Hashimotos encephalopathy associated with elevated intrathecal and serum IgG4 levels

Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials