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[58] Medical uses [edit] Treatment of deficiency [edit] Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 g of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 g

10.1001/jama.1926.02680070016005 35 MolloyA

A 10ml vial opened on day D potentially undergoes 30 to 50 successive punctures, each introducing micro-trauma to the septum and residual aerosol when the needle is withdrawn