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Adding a caloric deficit on top of declining estrogen and progesterone creates a fatigue picture that can feel overwhelming

GLP-1RAs have also been shown to attenuate vascular inflammation and oxidative stress, while preserving endothelial barrier integrity and limiting neutrophil infiltration in models of sepsis-associated acute lung injury (ALI) (Wiberg et al., 2018)

Second, people compare it to older weight loss drugs like fen-phen, which caused valvular heart disease

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