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Though UK-regulated products avoid illicit additives, airway inflammation, epithelial cell disruption, and subclinical alveolar injury have been noted in adolescent users, raising concern for early-onset chronic respiratory pathology

Implementing harm reduction strategies, such as recommending alternatives to smoking such as vaporization or oral formulations, could mitigate the inhalation of harmful byproducts

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Different Regulations Countries limit additives differently, which alters how cigarettes taste and how strong they feel

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