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Mitochondrial activity and chromatin structure in human sperm might be impaired by several toxins, therefore negatively affecting fertilization capacity both in vivo and in vitro [17, 33, 34]

Carcinogens and toxins have been found in the liquid used for vaporization and in the aerosols emitted, and e-cigarettes have been associated with an outbreak of cases of acute lung injury that caused hospitalizations and even deaths

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The nicotinic acetylcholine receptor agonists varenicline may cause dry mouth, exanthem, and acute generalised pustulosis

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