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Hepatocarcinogenesis with HBV and HCV develops when smoking is a cofactor [44] (Figure 3)

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Reducing tobacco use globally is an imperative for public health and for sustainable development

Krupka et al., 2016

He describes the plant (calling it petun), "which they [the natives of Brazil] ordinarily carry with them, because they consider it to be marvelous, [it] is profitable to many different things." 6 He explains how the natives smoked the tobacco, noting that they wrap the dried tobacco in palm leaves, "rolling it about the length of a candle, then set fire to one end, and receive the smoke from it by the nose and mouth." 7 Thevet mentions that he tried smoking it, but fainted ('I fell into a syncope') as a result