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Nicotine can also cause menopause to begin between 1 and 4 years earlier for women who smoke compared to non-smokers

The cough centre of the central nervous system (CNS) is believed to be in close proximity to the nucleus tractus solitarius (NTS), where the afferent nerves which mediate cough are known to synapse with second-order neurons (Figure 1)

Left untreated, neurosyphilis symptoms will worsen over time and can lead to death

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But if it happens over and over as when a person is smoking cigarette after cigarette, for example the arterial walls can become permanently damaged, and that damage can cause blood clots, heart attack or stroke

One quarter of the men who signed the Declaration of Independence were tobacco farmers