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However, sustaining such high levels of fake GLP-1 could cause you to produce less of your own endogenous GLP-1

The concept of permanent metabolic damage has been largely debunked by controlled research, though it remains a persistent myth in weight loss communities

Diabetes 60: 31033109

The most promising signal in the current research involves binge eating, and it is worth taking seriously, with some important clinical nuance attached

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Mutze J, Roth J, Gerstberger R, Hubschle T

This -cell dysfunction may reduce tirzepatides glycemic efficacy
