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Although CNO is often used as the inert ligand for DREADDs, studies show minimal, yet significant, reverse metabolism to clozapine, an active metabolite which could bind to non-DREADD receptors and produce off-target effects on behavior 31
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Post-transplantation diabetes mellitus
A similar study on those with diabetes did show a larger GLP-1 response, though only by about 15 percent
doi: 10.3389/fimmu.2016.00154 92 FriedrichMDiegelmannJSchauberJAuernhammerCJBrandS
This is why researchers at SeekPeptides emphasize understanding the mechanistic differences between drug classes
