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Overall, our results show significant reductions in the levels of HPHCs emitted by THS aerosol compared with cigarette smoke

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Some argue that e-cigarettes are a good substitute for regular cigarettes, and in some countries they are even promoted as a smoking cessation devices, but the CDC says that e-cigarettes are not safe for youth, young adults, and pregnant women, as well as adults who do not currently use tobacco products. A BMJ study published in February found that people who used e-cigarettes to quit smoking found them to be less helpful than more traditional smoking cessation aids

LCINS are highly enriched for targetable oncogenic alterations, have low tumour mutational burden and low rates of PD-L1 positivity, and lack mutational signatures, even in patients who report passive, secondhand smoke exposure

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