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Coronary artery disease occurs when the arteries that supply blood to the heart muscle become narrowed by plaque or blocked by clots

46,5658 This type of effect is seen in the CCL2-CCR2 signaling pathway between BC cell and TAMs that promote the initial recruitment of inflammatory macrophages to the premetastatic niche, where these macrophages evolve into metastasis-associated macrophages (MAMs)

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Among these, lung cancer remains the most lethal, accounting for more than 80% of tobacco-related cancer mortality
