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Cigarette smoke is considered one of the most powerful environmental modifiers of DNA methylation ( Figure 2 )

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Unlike urine or saliva tests, which can often be performed at home, blood tests involve drawing a sample from a vein, usually in the arm, and are processed in a clinical or laboratory setting

However, this direct cause-and-effect relationship between dopamine and nicotine eventually leads people to stop looking for other, healthier ways to release dopamine (exercise, deep breathing, hydration, meditation)