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New Research Adds to Concerns About Smokeless Tobacco Approximately 8 million Americans use smokeless tobacco products, regardless of the increased risk of oral cancer and periodontal disease

Such substances may cause substantial personal injury or illness during or as a result of customary use

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In vitro studies have shown altered gingival crevicular fluid inflammatory cytokine profiles (GCF) ,immune cell function and altered proteolylic regulation in smokers