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We are limited to concluding only that our data were consistent with our hypothesized and theory-guided mediational model, and acknowledge that alternative models with different causal assumptions (e.g., bi-directional relationships) may also fit the data equally as well

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From 2013 to 2024, the biggest increases were recorded for Brazil (with a CAGR of +16.1%), while consumption for the other global leaders experienced more modest paces of growth

Together, this growing preclinical evidence suggests that CBD could potentially be added to the standard detoxification regimen and mitigate acute or protracted withdrawal-related symptoms for several drugs of abuse, including opioids, psychostimulants, and alcohol