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Heres how it happens: Cigarette smoke contains over 5,000 chemicals, including tar and nicotine, which inflame and damage lung tissues

As previously referred, inflammatory pathways can also be activated by UVR-induced ROS or indirectly by DNA or mitochondrial damage, where both keratinocytes and fibroblasts contribute to the inflammatory condition and extracellular matrix degradation

doi: 10.1667/0033-7587(2002)157[0386:acsisf]2.0.co;2 24 NishimuraHLHernaultSW

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