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Obesity has emerged as a global health crisis, with the World Obesity Federation projecting that over 4 billion individuals will be either obese or overweight by 2035

GLP-1RAs and osteoclasts The greater degree of bone degradation observed in mice lacking GLP-1R indicates that GLP-1R signaling suppresses osteoclast differentiation and bone resorption

For patients with established CVD, semaglutide is the evidence-based choice

Design: Observational emulation of a target trial

"Mechanisms, Evaluation, and Management of Chronic Constipation in Adults." Gastroenterology , 2023

If finalized, it would close the bulks-list pathway entirely for these three GLP-1 substances