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Dosage Adjustment for Known CYP2D6 poor metabolizers and patient taking concomitant CYP2D6 inhibitors, CYP3A4 inhibitors, and/or CYP3A4 inducers CYP2D6 Poor Metabolizers: Should not be used (Health Canada)
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Some users find they need less frequent edible use compared to smoking, while others prefer smaller, more frequent smoked doses

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Healthrelated effects reported by electronic cigarette users in online forums