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It is not clear what the reason is

doi: 10.1016/s0265-931x(01)00146-1

The impact : Alcohol use is linked to increased rates of depression, anxiety, and even suicidal thoughts

Consider using nicotine replacement therapy to quit smoking and aim to reduce alcohol intake by setting limits and sticking to them

In cases of nicotine poisoning, the stomach should be quickly emptied, and repeated doses of tannic acid given, the person kept very warm in bed, and stimulants such as caffeine, strychnine, or atropine given, or if there are signs of respiratory failure, oxygen must be given at once

It crosses the blood-brain barrier and binds to dopamine transporters, blocking dopamine reuptake and causing its stimulating effects