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Increased levels of ROS contribute to inactivation of antiproteases (such as a1-antitrypsin) and activation of metalloproteases (MMPs), resulting in protease/antiprotease imbalance in the lungs, which directly contributes to the degradation of the lung matrix [94]

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The HM400 is rated to cover up to 1,500 square feet and achieves a smoke CADR that supports meaningful air changes per hour even in open-plan living spaces

Pediatrics (2019) 143(3):e20183144

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