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Most importantly, an interesting crosstalk between p53 and its VDR transcriptional target is also highlighted in SC suppression, which opens the way to promising pharmacological strategies involving synergistic combinations between mutp53 reactivators and vitamin D

Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia

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Shortening the telomeres, putting the DNA at increased risk to develop mutations

[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Guan L., Yang Y., Lu Y., Chen Y., Luo X., Xin D., Meng X., Shan Z., Jiang G., Wang F

Photoprotection by 1,25-dihydroxyvitamin D and analogs: Further studies on mechanisms and implications for UV-damage