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Biochemically, rats exposed to nicotine (2.5 mL/kg) showed a significant increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum due to hepatocyte cell death/damage

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Combined, these studies highlight just how easy it is for young people to purchase e-cigarettes online and evade policies intended to prevent youth use of nicotine-containing products

+ Direct comparison proves difficult because: Puff duration varies (1-5 seconds) Nicotine absorption differs between smoke and vapor Device power affects e-liquid consumption Individual technique impacts dosage Use puff counts as rough guidance while prioritizing craving satisfaction

Bonta noted that no judge has agreed with the tobacco industrys claims, and said it is time for allowing the will of the voters to take effect, as opposed to preserving a status quo that imperils the health of more young people in California with each passing day. Kagan referred the RJR appeal to the full court, which issued a brief order denying it without comment and with no dissents