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This study is a retrospective review of patients responses plus selected demographic and clinical variables extracted from the electronic health record

It must be noted that not every substance specified as a carcinogen would necessarily cause cancer

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According to StatPearls (NCBI), nicotine is one of several substances that affects ADH secretion, with research showing that acute nicotine exposure can suppress vasopressin release at higher doses allowing the kidneys to pass more water as urine

It's a form of communication disruption, not a tranquilizer