semaglutide belmont AAN 2026 Compounded Semaglutide (GLP-1) | Clinician-Prescribed

Approval (2017) RYBELSUS (semaglutide) tablets, for oral use

Where brand name Wegovy costs approximately $1,000 per month and brand name Zepbound runs about $1,086 per 28-day supply, compounded versions typically cost between $149 and $399 per month

No direct monotherapy trials compare the two, but separate data suggest similar benefits for blood sugar control

Programs were filtered against four criteria: clinician oversight (real review, not rubber-stamping), pharmacy quality (state-licensed, ideally 503(a) or 503B disclosure), pricing transparency (no surprise dose escalation), and refund-policy clarity (terms readable before paying)

A 3 mg once daily dose may be appropriate for some patients, if clinically indicated

Inclusion and Exclusion Criteria This NMA was guided by the PICOS framework (Population, Intervention, Comparison, Outcome, Study Design): Population: Individuals without documented hearing loss at baseline