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In 2018, 55.1% of smokers said they had made a quit attempt in the past year, with only 7.5% succeeding

University of Washington Press, Seattle, pp 1422 Benowitz NL (2009) Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics

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2) directly, since the lung possesses an extremely large surface area for gas exchange, it is possible that gas-phase cigarette smoke components interact with plasma constituents in the interstitial fluid

I give this two stars, but add an extra, because I would like to see others try this, and give thoughts