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Washington, DC: National Academies Press (US) 2010

Unfolded protein response (UPR) is a cellular defense mechanism to reduce protein-folding stress in the endoplasmic reticulum (ER)

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doi: 10.1016/j.jacc.2013.03.037 [36] Cornel JH, Ohman EM, Neely B et al
This periodic backwash helps to fluff the bed to eliminate channeling and to remove sediment and minerals that increase the pressure and reduce water flow
