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While there is no particular guidance on how to weight disparate pieces of evidence, this review classifies categories of data on a scale of 0 to 3, where consistency and interventions were given a threefold weight compared with other criteria, dose-response and biological plausibility were given a two fold weight, and the others were the comparator at a one fold weight (coherence, plausibility, and analogy), so that the maximum score was 45 (Supplementary Table 2, available online)

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