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Tirr E, Massimino M, Romano C, Pennisi MS, Stella S, Vitale SR, et al

VDR also regulates several other genes, in addition to MDM2 , that are targeted by p53 and its protein family, including the cell cycle regulator CDKN1A and several apoptotic effectors [145]

[DOI] [PubMed] [Google Scholar] 90.Ala-aho R., Grnman R., Seth P., Khri V.-M

Gambogic acid counteracts mutant p53 stability by inducing autophagy

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ROS and the metabolic adaptations which accompany ROS exposure, have now been shown to mediate cellular reprogramming by selecting for aggressive features, such as enhanced invasiveness and resistance to therapy