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Front Aging Neurosci 10:305

Wang W, Gao Y, Chen Y, Cheng M, Sang Y, Wei L, Dai R, Wang Y, Zhang L (2025) TGF- inhibitors: the future for prevention and treatment of liver fibrosis

A shift in cytokine expression and activation of the NF-B pathway, leading to inflammation, occurred following vaccine administration

this enables translated NRF2 to be translocated to the nucleus and stimulate transcription of genes with antioxidant response elements (AREs) (87, 88)

The improperly repaired DNA damage further activates cell cycle checkpoint proteins, such as p53 and p16INK4, and leads up to the onset of premature senescence (Romero et al., 2016)