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Mechanistic plausibility exists for tissueprotective and reparative effects through modulation of angiogenesis, NO signaling, and inflammatory pathways, but translation into standardized therapeutic regimens for humans remains to be established by rigorous clinical research

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Bacteria are exquisitely sensitive to environmental cues and can initiate new genetic programs within minutes of detecting changes in resource availability (i.e., iron, phosphate, nitrogen, carbohydrates, or oxygen,), signals from other stressed or damaged bacteria (i.e., acyl-homoserine lactones or autoinducing peptides), or host signals of damage or inflammation (i.e., temperature, products of host cell damage, cytokines, or neurotransmitters) [59,60,61,62,63,64,65,66]

Hopkins RG, Failla ML

My arm was no longer sore