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When nicotine enters the brain, it can actually bind to the same receptors that bind acetylcholine

On the other hand, if a gene is relatively unencumbered, then it might be expressed at higher levels than normal

Studies show that the risk of heart disease among light smokers is still significantly higher than among non-smokers, with a 30% to 50% increase in the risk of heart attacks and strokes

However, many active shotgun users consider this to be overstated, and view bolo shells as being less effective than conventional ammunition