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First, we observed a significant positive association between smoking and HTN, which exhibited a clear potential dose-response relationship with cigarette consumption

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However, the significant correlation between the number of cigarettes smoked per day and the fasting levels of glucose and C-peptide is consistent with a nicotine-related reduction in maternal insulin sensitivity

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Our results show that CS exposure using the CFAX12 induced a ~ 60% reduction in trans-barrier electrical resistance (TER), increased ROS generation depending on cellular model complexity, and a ~ 4.5-fold increase in IL-8 gene expression, all key hallmarks of early COPD pathogenesis