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Regardless of the underlying condition, however, the primary mechanism of heartburn is related to the opening and closing of the lower esophageal sphincter

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Many characteristics of these trials, such as short durations, confined settings and choice of comparators and participants, are not representative of real-world use and fail to adequately investigate whether HTPs reduce harm and are beneficial to public health. The authors overall conclusion is that: The conduct and reporting of HTP interventional clinical trials were poor in many respects and limited to investigating effects of short-term exposure