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The abnormal distribution of gap junction proteins such as GJA1 (also known as connexin 43), and GJA5 (connexin 40), causes non-uniformity of electrical conduction, thus causing the arrhythmia

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Furthermore, the RhoA/ROCK pathway plays an important role in the onset, maintenance, and progression of vascular injury through vasoconstriction and remodeling [81, 82]

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